myasthenia gravis in children and adolescents
نویسندگان
چکیده
myasthenia gravis (mg) is a disorder of the neuromuscular junction. in children, the disease may be congenital or due to an autoimmune process. clinical manifestations may be purely ocular or may include generalized weakness, fatigability, dysphagia, and disorders of speech. in this article, 27 children (14 female, 13 male) were prospectively studied from birth to age fifteen. disease presentation was ocular in all the cases, with ptosis and diplopia. in 6 patients (all female), the disease was purely ocular, in the remaining 21, the disease was generalized. there was one case of transient neonatal myasthenia born to a myasthenic mother. nine patients underwent thymectomy; all were reported as hyperplasia. clinical consequences of the surgery were satisfactory. five cases had hereditary myasthenia. in three brothers from one family, and a brother and sister from another family, disease presented from the neonatal period. overall, compared to adults, myasthenia seems to have a more favorable course in children. in the autoimmune form of the disease, thymectomy has a very good result. thymoma was not observed in these cases. mg in the newborn of myasthenic mothers had a very good prognosis, and treatment is necessary in the first few weeks only in the presence of clinical manifestations. in the congenital form of the disease, there is no indication for administration of steroids, thymectomy, or plasmapheresis.
منابع مشابه
Myasthenia gravis in children:
Since its recognition as a clinical entity by Wilks in 1877 and Erb in 1879, myasthenia gravis has been considered a rare condition in children. The commonest age of onset is in the third decade, with a higher incidence in women than in men. Early collections of case records mentioned few patients affected before the tenth year. Palmer (1908) from an eight-year period collected 126 records; in ...
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A case of myasthenia gravis in a 15 years old girl is pre·sented. The disease was present for 5 years before thymectomy was performed. Indications for thymectomy, preoperative preparation, anesthetic and surgical management is -discussed.
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A retrospective comparative study was performed on 54 patients treated medically or surgically (thymectomy) for myasthenia gravis (MG) from 1979- 1989 in three Shiraz University Hospitals. Each surgical patient was compared with a medical patient on the basis of age, sex, severity and duration of disease. Complete remission was noted in 3 out of 27 thymectomized patients but in none of the...
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Introduction: Myasthenia gravis is a disease of neuromuscular junction. Familial cases have been reported. Relation between myasthenia gravis and HLA antigens has been seen in many studies from different parts of the world. The aim of this study is determination of association between HLA class I haplotypes and myasthenia gravis in Kerman province. Methods: In this cross sectional study 44 my...
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عنوان ژورنال:
acta medica iranicaجلد ۳۲، شماره ۱-۲، صفحات ۱۲-۲۰
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